منابع مشابه
The coagulopathy of sepsis: pathophysiology and management.
Sepsis is an infection-induced inflammatory syndrome that results in a complex network of adaptive and maladaptive alterations in homeostatic mechanisms. Severe sepsis, defined as sepsis associated with acute organ failure, is a serious disease with a mortality rate of 30-50%. The coagulation system, through complex interactions, has an important role in the final outcome of the sepsis-induced ...
متن کاملAcute traumatic coagulopathy.
PURPOSE OF REVIEW Recent therapeutic and observational studies have demonstrated improved survival with better management of haemostasis early after injury. This review delineates our current understanding of the clinical importance, aetiology and pathophysiology of acute traumatic coagulopathy (ATC). RECENT FINDINGS Trauma causes an acute disruption of the equilibrium between all components ...
متن کاملAcute traumatic coagulopathy.
PURPOSE OF REVIEW Mortality from trauma remains a global public health challenge, with most preventable deaths due to bleeding. The recognition of acute traumatic coagulopathy as a distinct clinical entity characterized by early coagulation dysfunction, arising prior to medical intervention, has revolutionized trauma management over the last decade. The aim of this article is to review our curr...
متن کاملAcute coagulopathy of trauma in the rat.
INTRODUCTION Acute coagulopathy of trauma (aCOT) is a state of disordered coagulation developing soon after severe injury and blood loss and has been defined in the clinical literature as an elevation in prothrombin time (PT) and activated partial thromboplastin time (aPTT). OBJECTIVE The purpose of this study was to develop a rat model of aCOT resulting from polytrauma and hemorrhage and sho...
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ژورنال
عنوان ژورنال: Current Opinion in Anaesthesiology
سال: 2015
ISSN: 0952-7907
DOI: 10.1097/aco.0000000000000163